Depakote and Valproic Acid

It is necessary to know which medications help against epilepsy, to know how to apply them and to monitor their administration in a timely manner by a sick person. The frequency of seizures and strength depend on how well the treatment is selected.

Depakote ER/500mg, 250mg:


Buy Depakote Online

Depakote (generic name: valproate semisodium / divalproex sodium / valproic acid; brand names include: Divaa) is a compound that contains sodium valproate and valproic acid.

Depakote is indicated for the treatment of:

  • Acute manic or mixed episodes associated with bipolar disorder, with or without psychotic features;
  • Manic episodes associated with bipolar disorder;
  • Complex partial seizures, and simple and complex absence seizures in adults and children 10 years of age and older with epilepsy.

Depakote is also indicated for the prevention of migraine headaches in adults.

You can see the price for Depakote in a dosage of 500 mg and 250 mg. To buy, click on the picture or link below it.

Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part of you do not understand. Take Depakote exactly as directed.

Valproic Acid

Chemical properties

This chemical is a fatty acid derivative. The acid is liquid at room temperature, sodium salt is used for medical purposes. Sodium valproate is a white solid, a fine powder that dissolves well in alcohol and water. Molecular weight = 144.2 grams per mole.
Produced in the form of tablets, tablets in the enteric coating, long-acting tablets, capsules, syrup or solution for ingestion, in the form of a solution for injection.

Pharmachologic effect

Sedative, antiepileptic, muscle relaxant.

Pharmacodynamics and pharmacokinetics

Valproic Acid improves the mental state of patients, has a sedative, central muscle relaxant and direct cardiotropic action. To this day, the mechanism of action of the drug is not fully understood. It is believed that the substance stimulates the work of the GABAergic system, inhibiting the enzyme GABA-transferase, which causes a decrease in the concentration of GABA in the nervous system. Also, the agent acts directly on the postsynaptic receptors (GABA-A receptor) that mimic or enhance the effect of the substance on the nervous system. In addition, the acid affects the operation of potential-dependent sodium channels, affects the activity of semi-impermeable membranes, and changes the conductivity of K. ions.

The substance after oral administration is completely and quickly absorbed in the digestive tract. Next, the agent dissociates to valproate ion and penetrates into the blood plasma. The degree of bioavailability is 93%. The degree of absorption does not depend on the intake of food. The maximum concentration of the drug in the blood reaches within 3 hours.
The equilibrium concentration of the drug will be observed on the 2nd-4th day of treatment. The substance has a sufficiently high degree of association with albumin blood – up to 95%. The medicine penetrates through the BBB, it is released during lactation. Metabolism occurs in the liver, where Valproic Acid is subjected to oxidation and glucuronization.
The medicine is withdrawn with the help of the kidneys. The half-life is between 8 and 20 hours. When combined with other drugs, if induction of metabolic enzymes is observed, the elimination half-life is reduced to 8 hours.